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. 2005 Mar;25(5):1696–1712. doi: 10.1128/MCB.25.5.1696-1712.2005

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Copyright © 2005, American Society for Microbiology

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FIG. 7. — Retardation of hair follicle development in Akt1-knockout mice. (A) Representative staining of endogenous alkaline phosphatase in Akt1 heterozygous (Akt1^+/−) and Akt1-knockout (Akt1^−/−) skin at P1 (left panels) and P4 (right panels) are given. Arrowheads indicate the persistence of early HFs in the Akt1^−/− skin. (B) The hair scores (left panel) and detailed analysis of the percentage of HFs at distinct stages of morphogenesis (right panel) in three different Akt1^+/− and Akt1^−/− skin were assessed by quantitative histomorphometry at the indicated developmental age. (C) Skin sections of Akt1^+/− and Akt1^−/− mice at P4 were stained with hematoxylin-eosin (left panels), and the thickness of total skin and hypodermis were determined by histomorphometry (right panel). Independent Student's t test: *, P < 0.05; **, P < 0.01. Magnification bars, 50 μm.