Table 2.
Top 10 up or downregulated pathways in microarray #1 (neonates compared to fetuses).
| MAPP name | Z score | P value | |
|---|---|---|---|
| Upregulated (ratio > 2.0) | |||
| 1 | Mm_Fatty_acid_metabolism | 5.34 | 0 |
| 2 | Mm_Tryptophan_metabolism | 4.68 | 0 |
| 3 | Mm_Fatty_Acid_Beta_Oxidation_WP1269_34394 | 4.42 | 0 |
| 4 | Mm_Triacylglyceride_Synthesis_WP386_21490 | 4.79 | 0.001 |
| 5 | Mm_Fatty_Acid_Beta_Oxidation_1_WP221_21143 | 4.23 | 0.001 |
| 6 | Mm_Bile_acid_biosynthesis | 4.23 | 0.004 |
| 7 | Mm_Mitochondrial_LC-Fatty_Acid_Beta-Oxidation_WP401_34420 | 4.25 | 0.005 |
| 8 | Mm_Butanoate_metabolism | 3.89 | 0.006 |
| 9 | Mm_Complement_and_Coagulation_Cascades_KEGG_WP449_33690 | 3.25 | 0.006 |
| 10 | Mm_gamma_Hexachlorocyclohexane_degradation | 3.09 | 0.012 |
| Downregulated (ratio < 0.5) | |||
| 1 | Mm_Cell_cycle_WP190_35363 | 8.10 | 0 |
| 2 | Mm_DNA_Replication_WP150_35196 | 7.99 | 0 |
| 3 | Mm_G1_to_S_cell_cycle_control_WP413_35821 | 5.64 | 0 |
| 4 | Mm_Glycolysis_and_Gluconeogenesis_WP157_34413 | 4.23 | 0.002 |
| 5 | Mm_One_Carbon_Metabolism_WP435_34970 | 3.61 | 0.003 |
| 6 | Mm_Nucleotide_Metabolism_WP87_33534 | 3.29 | 0.005 |
| 7 | Mm_Starch_and_sucrose_metabolism | 2.86 | 0.008 |
| 8 | Mm_Pentose_phosphate_pathway | 2.97 | 0.013 |
| 9 | Mm_Glycolysis_Gluconeogenesis | 2.52 | 0.018 |
| 10 | Mm_One_carbon_pool_by_folate | 2.84 | 0.024 |
MAPP = Map Annotator and Pathway Profiler.