Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jun 30;7:4416. doi: 10.1038/s41598-017-03733-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

QS-mediated post-secretional activation of PIV. The initial expression of both PIV and LasB is positively regulated by QS. The prepro-PIV in cytoplasm is processed twice from N-terminus during secretion to release signal peptide, propeptide, and mature PIV in extracellular space. The mature PIV is inhibited by the propeptide binding. The mature LasB then degrades the propeptide to release activate PIV. LasB is also processed in a similar manner and inhibited by its propeptide (PP_LasB). The processing of pro-LasB to mature LasB is achieved by auto-cleavage. SP, signal peptide; PP, propeptide.