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. 2017 Jun 30;7:4469. doi: 10.1038/s41598-017-04736-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RAD51-AS1 silencing regulates the expression of p53 and p53-related genes. (A), The silencing efficiency of RAD51-AS1 in microarray samples was validated by qRT-PCR. (B), The mRNA levels of p53-related genes in SKOV3.ip cells were detected by qRT-PCR after RAD51-AS1 knockdown. The results confirm the microarray data, and the mRNA level of predicted RAD51-AS1 target genes (TYRO3 and IVD) was not affected. (C), The protein levels of p53-related genes were detected by Western blotting after RAD51-AS1 knockdown. No changes were observed in the protein levels of TYRO3 and IVD. (D), Representative p53 IHC images in EOC patient samples. (E), The correlation between p53 and RAD51-AS1 expression in patient samples (Spearman Correlation analysis, P < 0.001, r = −0.269). All results are shown as the mean ± SD and are representative of three independent experiments. (*P < 0.05; **P < 0.01; ***P < 0.001 by Student’s t test).