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. 2017 Jun 30;7:4430. doi: 10.1038/s41598-017-04818-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ANKRD22 promoted the expression of E2F1 gene. (A) The transcriptional activation of E2F1 by ANKRD22 was detected by luciferase assays. (B) Overexpression of ANKRD22 increased and knockdown of ANKRD22 decreased the mRNA and protein expression levels of E2F1 in H1299 cells. Full-length blots are presented in Supplementary Figure S7. (C) Correlation between the relative expressions of E2F1 and ANKRD22 in specimens from NSCLC patients expressed using linear regression (solid line). (D) RNA polymerase II (RNA Pol II) signal in the E2F1 promoter region was detected by chromatin immunoprecipitation (ChIP) assay. (n = 3, *P < 0.05).