Table 1. Immunostaining of human RCC tumours from BHD patients.

Tissue	pERK	pS6
Normal kidney parenchyma	Glomeruli and collecting ducts are positive
Patient 1—RCC chromophobe	++	+/−
*Patient 2—RCC clear cell	++	++
*Patient 2—RCC oncocytoma	++	++
†Patient 3—RCC oncocytoma	—	—
†Patient 3—RCC chromophilic	+	—
Patient 4—chromophobe/oncocytoma hybrid	++	+/−

++, strongly positive in a large percentage of the tumour; +, positive, +/−, focal areas of positivity.

^*Denotes tumours from the same patient.

^†Denotes tumours from the same patient.