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The ubiquitin proteasome system. Ubiquitylation occurs through the subsequent actions of E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme) and E3 enzymes (ubiquitin ligase) on the mediation of ubiquitin ligation to target proteins. DUBs counteract E3 ligase-mediated ubiquitylation and recycle the ubiquitin molecules for further use.
