FIG. 7.

Cell size in Akt1-deficient brains and hearts. (A and B) Sections of cortex stained with Hoechst 33258. Bar = 50 μm. (C) Mean cell areas based on nuclear densities. (D and E) Micrographs of sections of hearts from Akt1 knockout mice (E) and littermate controls (D) were stained with FITC-conjugated wheat germ agglutinin (green) and propidium iodide (red). (F) The mean cell area of cardiomyocytes is represented as a percentage of the mean wild-type control value. Values are means ± SD (N = 3). *, P < 0.01 for Akt1 knockout myocyte size versus wild-type control size.