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. 2017 Jun 14;14(131):20170332. doi: 10.1098/rsif.2017.0332

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© 2017 The Author(s).

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 4. — Reconstructing the model error for the JAK–STAT signalling pathway [19]. (a) Nominal model of the JAK–STAT signalling (blue) including its nucleocytoplasmic cycling (red). (b,c) Measurements (black) for phosphorylated cytoplasmic STAT5 and total cytoplasmic STAT5 and posterior BDEN predictions including the 95% credible intervals (red) based on the nominal system (blue). (d) Estimated hidden inputs (posterior means) and 95% credible intervals. There is a clear input located at STAT5 and STAT5 in the nucleus. (e) Estimated time series posterior means for all modelled variables including 95% credible intervals. (f) Estimated correlations (Corr) and cross-correlations (xCorr) of the estimated hidden input located at STAT5 with all estimated state variables. (g) Estimated correlations and cross-correlations of with all remaining hidden influences. Here is clearly correlated to the hidden input located at STAT5_n and in addition it is correlated to the time series of STAT5_n. High cross-correlation is a necessary but not sufficient condition.

Inline graphic — Reconstructing the model error for the JAK–STAT signalling pathway [19]. (a) Nominal model of the JAK–STAT signalling (blue) including its nucleocytoplasmic cycling (red). (b,c) Measurements (black) for phosphorylated cytoplasmic STAT5 and total cytoplasmic STAT5 and posterior BDEN predictions including the 95% credible intervals (red) based on the nominal system (blue). (d) Estimated hidden inputs (posterior means) and 95% credible intervals. There is a clear input located at STAT5 and STAT5 in the nucleus. (e) Estimated time series posterior means for all modelled variables including 95% credible intervals. (f) Estimated correlations (Corr) and cross-correlations (xCorr) of the estimated hidden input located at STAT5 with all estimated state variables. (g) Estimated correlations and cross-correlations of with all remaining hidden influences. Here is clearly correlated to the hidden input located at STAT5_n and in addition it is correlated to the time series of STAT5_n. High cross-correlation is a necessary but not sufficient condition.