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. 2017 Jun 14;14(131):20170332. doi: 10.1098/rsif.2017.0332

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© 2017 The Author(s).

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 5. — Reconstructing the hidden influence in a model of the EpoR regulation [37]. (a) Reaction graph of the model (E = Epo, ER = EpoR, EER = Epo − EpoR, EER_i = Epo − EpoR_i, dE_i = dEpo_i, dE_e = dEpo_e). The red arrow is a wrong reaction. (b,c,d) Output measurements (black) compared with posterior BDEN predictions (red) including 95% credible intervals and the nominal model (blue). (e) Estimates of the hidden influences (posterior mean) including 95% credible intervals. (f) Estimated correlations (Corr) and cross-correlations (xCorr) of the hidden influence related to w_E with all estimated state variables. A clear correlation with EpoR is observable. (g) Estimated correlations (Corr) and cross-correlations (xCorr) of the hidden influence related to w_E with all estimated remaining hidden influences. Again w_E is clearly correlated with w_ER. In consequence, the direct interaction between ER and E is correctly classified as wrong and has to be removed.