Table 1.
Genotype distribution, allele frequencies and association analysis of the rs3892097 (G/A) polymorphism in Pakistani population
| Genotype distribution | |||||
| GG | GA | AA | Total | HWE (p-value) | |
| PD | 145 (83.3%) | 21 (12.0%) | 8 (4.5%) | 174 | 0.89 |
| Control | 182 (91.0%) | 18 (9.0%) | 0 (0%) | 200 | 0.95 |
| Total | 327 | 39 | 8 | 374 | 0.92 |
| Allelic distribution | |||||
| G | A | Total | |||
| PD | 311 (89.3%) | 37 (10.6%) | 348 | ||
| Control | 382 (95.5%) | 18 (4.4%) | 400 | ||
| Total | 694 | 55 | 748 | ||
| Genetic model and statistical data | |||||
| Genetic model | Odds ratio (95% CI) | Chi-square | Degrees of freedom | P | |
| Allele contrast (G vs. A) |
2.52 (1.40-4.52) | 10.27 | 1 | 0.001 | |
| Dominant (GA + AA vs. GG) |
2.02 (1.07-3.78) | 4.97 | 1 | 0.02 | |
| Recessive (AA vs GG + GA) |
Infinitea | 9.23 | 1 | 0.002 | |
aThe OR and 95% CI of the recessive model could not be calculated since there was no homozygous CYP2D6*4 observed in the control group