Figure 1.

Splicing pattern of HIV-1. The genomic organization of HIV-1 is depicted on top with open boxes representing ORFs and 5′ and 3′ LTRs, respectively. Classes of Rev-dependent RNAs are shown below on the left side, Rev-independent RNAs on the right side. A circle represents the 5′ cap, translated reading frames are depicted as open boxes, the RRE as a black box, and 5′ and 3′ss as arrows and vertical lines, respectively. The nomenclature of splice sites was adapted from Purcell and Martin, (8). Below each RNA, the splice sites used for its generation and the translation product are identified.