Figure 8. . Effect of anionic silica nanoparticles on 1D ¹H and 2D ¹³C-¹H HSQC spectra of 10-compound metabolite model mixture consisting of lysine, arginine, histidine, citric acid, lactic acid, shikimic acid, alanine, dimethylglycine, glucose and valine 2 mM each (A) without and (B) with anionic silica nanoparticles.

Blue squares highlight the cross-peaks of lysine, arginine, histidine and dimethylglycine that are suppressed in the presence of silica nanoparticles (red squares).

Reproduced with permission from [92] © American Chemical Society (2015).