Table 2.4.
Dehydrogenases and reductases likely to contribute physiologically to RA homeostasis1
| Mouse | Rat | Human | Function |
|---|---|---|---|
| Rdh1 (9C17) | Rdh2, Rdh7 (9C28, 9C29) (RodhII, RoDHIII) | RDH16 (9C8) (RODH4, RDH-E) | Dehydrogenase |
| Rdh10 (16C15) | RDH10 (16C4) | Dehydrogenase | |
| Rdh10 (16C10) | Dhrs9 (9C26) (eRolDH, Rdhl) | DHRS9 (9C4) (retSDR8, RDHL, Rdh-TBE, RoDH-E2, 3α-HSD) | Dehydrogenase |
| SDR16C5 (16C114) | RDHE2 (16C5) | Dehydrogenase | |
| Dhrs9 (9C12) (Rdh15) | SDR16c6 (16C113) | a SDR (16C6P) | Dehydrogenase |
| Rdhe2 (16C11) (Scdr9, Sdr16c5) | – | RDH14 (7C4) | Dehydrogenase |
| Rdhe2S (16C12) (SDR16c6) | (PAN2) | Reductase | |
| Rdh14 (7C12) | Dhrs3 (16C16) | DHRS3 (16C1) (RDH17, SDR1, SDR16C1, retSDR1, Rsdr1) | |
| Dhrs3 (16C9) | Dhrs4 (25C7) (PSCD) | DHRS4 (25C2) (SCAD-SRL, SDR-SRL) | Reductase |
| (retSDR1, Rsdr1) | Rdh11 (7C14) | Rdh11 (7C1) (PSDR1, RalR1) | Reductase |
| Dhrs4 (25C5) (RRD) | – | RDH13 (7C3) | Reductase |
| Rdh11 (7C9) (SCALD, Psdr1) | |||
| Rdh13 (7C11) |
1
All belong to the SDR gene family. Orthologs are aligned in rows. “Family designations” are given in parentheses next to each human gene, each is preceded by SDR, e.g. SDR9C8 [202, 203]. Alternative names are given in parentheses below. Several genes were cloned multiple times and named differently. Various nomenclature initiatives introduced further confusion by assigning different common names to orthologs (e.g. mRDH1, rRDH2, hRDH16)
a
This is a pseudo gene in human. –, no entry for rat