Table 3.
Comparison of Patient Characteristics and histology by Stage of Fibrosis at First Biopsy
| Characteristic at First Biopsy | Stage of Fibrosis at First Biopsy | p-Value | ||
|---|---|---|---|---|
| None (N=7) | Portal/Peri-Portal (N=32) | Bridging/Cirrhosis (N=5) | ||
| Age (Yrs) * | 9.9 (3.9) | 8.0 (4.1) | 11.0 (3.7) | 0.22 |
| Duration (Yrs) * | 9.3 (4.2) | 7.0 (4.0) | 10.0 (5.6) | 0.19 |
| HCV RNA × 106 * (IU/ml) | 1.6 (2.1) | 0.6 (0.8) | -- | 0.11 |
| ALT (U/L) * | 56 (29) | 94 (81) | 118 (56) | 0.34 |
| BMI Z-Score * | 0.97 (0.94) | 0.12 (1.50) | 0.72 (0.39) | 0.28 |
| Gender (Male) % (n) | 43% (3) | 50% (16) | 0% (0) | 0.03 |
| Transmission (Vertical) % (n) | 43% (3) | 59% (19) | 60% (3) | 0.68 |
| Genotype - % (n) | ||||
| 1 | 100% (7) | 88% (22) | 50% (1) | 0.11 |
| 2 | 0% (0) | 6% (2) | 50% (1) | |
| 3 | 0% (0) | 6% (2) | 0% (0) | |
| Steatosis % (n) | ||||
| None | 71% (5) | 78% (25) | 80% (4) | 0.15 |
| Mild/Moderate | 29% (2) | 22% (7) | 20% (1) | |
| Grade % (n) | <0.0001 | |||
| None/Minimal | 100% (7) | 53% (17) | 0% (0) | |
| Mild | 0% (0) | 25% (8) | 0% (0) | |
| Moderate | 0% (0) | 22% (7) | 40% (2) | |
| Marked | 0% (0) | 0% (0) | 60% (3) | |
*
Mean (± S.D.)