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. 2005 Feb 16;33(3):946–954. doi: 10.1093/nar/gki236

Figure 1.

Figure 1

Schematic overview of autonomous TEs and retroviruses and their protein content. The highlighted domains are characteristic for these elements and correspond to marker domains used in this study. (A) Protein content of most common vertebrate retrotransposons and DNA transposons. The single ORF of DNA transposons encoding a transposase is depicted. LINEs contain two open reading frames (ORF1 and ORF2): encoding an RNA-binding protein and a pol gene with homology to reverse transcriptases and endonucleases. LTR-retrotransposons can include ORFs such as (i) gag, encoding a protein that forms the structural component of a cytoplasmic particle within which reverse transcription reaction takes place and (ii) pol, which encodes in most elements an aspartic protease (Pro), a reverse transcriptase (RT), a ribonuclease H (RNase H) and an integrase (Int). These elements can also include an env protein and, thus, show a protein content very similar to the endogenous retrovirus. (B) Protein content of retroviruses. In comparison to an endogenous retrovirus, a retrovirus possesses additional proteins that are usually not recognizable in endogenous retrovirus.