Table 3.

Multiple Linear Regression Models for Endogenous Thrombin Potential and Clot Lysis Time Taking into Account Interleukin 6, Tumor Necrosis Factor α, and Periostin

Endogenous thrombin potential
	Control			Asthma
	β	95% CI	R 2	β	95% CI	R 2
Age, years			0.4	0.03	−0.05 to 0.11	0.37
Body mass index, kg/m2	0.16a	0.01 to 0.31		0.2a	0.12 to 0.28
FEV1/VC				–0.09a	−0.17 to −0.01
Blood platelet count, 103/μl				0.17a	0.09 to 0.25
Total cholesterol, mmol/l				0.16a	0.08 to 0.24
Factor II, %	0.38a	0.23 to 0.53		0.19a	0.12 to 0.26
hsCRP, mg/l	0.15	−0.01 to 0.31		0.13a	0.03 to 0.23
Immunoglobulin E (log10), IU/ml	0.26a	0.12 to 0.40
Interleukin 6, pg/ml	0.01	−0.16 to 0.18		0.17a	0.08 to 0.26
Tumor necrosis factor α, pg/ml	0.07	−0.08 to 0.22		0.04	−0.04 to 0.12
Periostin, ng/ml				0.02	−0.06 to 0.1
α2-macroglobulin, nmol/l	0.30a	0.14 to 0.45		0.34a	0.27 to 0.41
Plasminogen, %				0.09a	0.02 to 0.16
Platelet factor 4, ng/ml				0.01	−0.06 to 0.8
Adjustment statistics	F = 3.29, p = 0.009			F =  6.9, p < 0.001
Clot lysis time
	Control			Asthma
	β	95% CI	R 2	β	95% CI	R 2
FEV1/VC			0.51	−0.11a	−0.19 to −0,03	0.25
Blood platelet count, 103/μl	0.14a	0.01 to 0.27
White blood cells, 103/μl	0.15a	0.03 to 0.27		0.01	−0.07 to 0.09
Total cholesterol, mmol/l	0.13a	0.01 to 0.25		0.15a	0.07 to 0.23
Triglycerides, mmol/l	0.19a	0.16 to 0.31
Glucose, mmol/l	0.2a	0.06 to 0.34
hsCRP, mg/l	−0.21a	−0.35 to −0.07		0.08	−0.02 to 0.18
Immunoglobulin E (log10), IU/ml				−0.23a	−0.31 to −0.15
Antithrombin, %				−0.11a	−0.19 to −0,03
ETP, nmol/l thrombin x min.	−0.21a	−0.33 to −0.09		0.17a	0.12 to 0.26
Plasminogen, %	0.2a	0.08 to 0.32		0.06	−0.02 to 0.14
Interleukin 6, pg/ml	−0.002	−0.152 to 0.148		−0.05	−0.15 to 0.05
Tumor necrosis factor α, pg/ml	0.31a	0.16 to 0.46		0.15a	0.07 to 0.23
Periostin, ng/ml				0.04	−0.04 to 0.12
Antiplasmin, %	0.3a	0.17 to 0.43
Plasminogen activator inhibitor-1, ng/ml	0.35a	0.22 to 0.48		0.28a	0.2 to 0.36
P-selectin, ng/ml	−0.26a	−0.4 to −0.12		−0.2a	−0.28 to −0.12
Adjustment statistics	F =  4.2, p = 0.0006			F =  4.37, p < 0.001

The resulting standardized regression coefficient (β) (with 95% confidence intervals [95% CI]) for a factor (independent variable) indicates the increase/decrease in standard deviations (SDs) of dependent variable, when that particular factor increases with 1 SD and all other variables in the model are unchanged

FEV ₁ /VC forced expiratory volume in 1 s/vital capacity, hsCRP high-sensitivity C-reactive protein, ETP endogenous thrombin potential

^aStatistically significant