Table 1.
Etiology of hypopituitarism in all enrolled patients (N = 512).
| No. | % | ||
|---|---|---|---|
| Congenital hypopituitarism | 74 | (14.6) | |
| Head trauma | Trauma brain injury | 20 | (4.0) |
| Subarachnoid hemorrhage | 7 | (1.4) | |
| Extrapituitary cranial irradiation | 18 | (3.5) | |
| Pituitary tumors | Acromegaly and gigantism | 37 | (7.2) |
| Prolactinomas | 36 | (7.0) | |
| Nonfunctional pituitary tumors | 205 | (40.5) | |
| Cushing's disease | 10 | (2.0) | |
| Pituitary cyst | 9 | (1.8) | |
| Tumors of sellar region | Craniopharyngioma | 30 | (5.9) |
| Germinoma | 7 | (1.4) | |
| Meningioma, chondroma, granulosa cell tumor | 4 | (0.8) | |
| Metastasis | 2 | (0.4) | |
| Infections | Viral | 18 | (3.5) |
| Tuberculosis | 1 | (0.2) | |
| Fungal | 2 | (0.4) | |
| Vascular disorders | Sheehan's syndrome | 6 | (1.2) |
| Pituitary apoplexy | 2 | (0.4) | |
| Aneurysm | 3 | (0.6) | |
| Inflammations/infiltrations | Lymphocytic hypophysitis | 8 | (1.6) |
| Histiocytosis X | 3 | (0.6) | |
| Empty sella | 6 | (1.2) | |
| Other | •CHARGE Sy, ••Leukodistropy 4H Sy | 2 | (0.4) |
| Idiopathic | 2 | (0.2) | |
•CHARGE Sy includes coloboma of the eye, heart defects, atresia of the choanae, retardation of growth and/or development, genital abnormalities, and ear abnormalities.
••Leukodystrophy 4H Sy includes hypomyelination, hypogonadotropic hypogonadism, and dental developmental anomalies.