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. 2005 Feb 17;33(3):1010–1020. doi: 10.1093/nar/gki245

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© The Author 2005. Published by Oxford University Press. All rights reserved

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Schematic representation and nucleotide sequence of prothrombin variants expressed using the vectors harbouring the mutated SV40 polyadenylation signal. Indicated in the figure: the mutated prothrombin upstream sequence element (USEmut); AAUAAA, prothrombin (PT) polyadenylation signal; CG/CA, prothrombin polymorphic cleavage site; 50 bp prothrombin downstream genomic sequence (DGS); cryptic 3′ cleavage site; mutated SV40 polyadenylation signal (gcgcgA); SV40 cleavage site, AC. Due to the presence of adenine residues downstream of the indicated cryptic (1–3 nt) and SV40 (1–2 nt) sites, it is not possible to ascertain the exact site of cleavage by sequencing due to the presence of the poly (A) tail. For simplicity only the last non-adenine residue is indicated as the position of the cryptic and SV40 cleavage sites.