Figure 1.

Expected ROS-mediated effects of targeted therapies. In addition to the respective signalling pathway that a targeted agent affects, the diagram represents their putative ROS-related effects. CRC: colorectal cancer; GISTs: gastrointestinal stromal tumours; RCC: renal cell carcinoma; ROS: reactive oxygen species; O₂^•−: superoxide; H₂O₂: hydrogen peroxide; NO^•: nitric oxide; ΔΨ: mitochondrial membrane polarity; TCA: tricarboxylic acid cycle; m: methylation; NFE2L2: nuclear factor erythroid 2-related factor 2.