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. 2017 Jul 1;12:51. doi: 10.1186/s13024-017-0191-y

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Validation of miRNAs associated with AD in other studies. The relationship between average miRNA expression (x-axis) and association with pathological AD in ROSMAP (y-axis) is plotted for each miRNA. The association between a miRNA and AD is calculated as a z-score after correcting for other factors; a negative z-score denotes decreased miRNA expression in the context of AD. Previously reported miRNAs [12] are highlighted by colored triangles, with red denoting higher expression in AD and blue reduced expression in AD in the original publication. The dotted horizontal line marks the z-score threshold of significance that is equivalent to a Bonferroni p-value cut-off of 0.05; none of the miRNAs with positively correlated expression are significantly associated with AD. The gray circles represent all other miRNAs tested in our study