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. Author manuscript; available in PMC: 2017 Jul 2.
Published in final edited form as: J Control Release. 2016 Nov 1;244(Pt A):1–13. doi: 10.1016/j.jconrel.2016.10.026

Fig. 4.

Fig. 4

Efficacy from single IVT injection of dual dAb-loaded microparticles into Cynomolgus eye. (A) Schematic efficacy experimental design, MP = microparticles. (B) Representative fluorescein angiograms (FA), 14 days after 2nd laser (Table 3) from empty (Group 1) and dual dAb-loaded (Group 2) microparticle dosed animals and positive control, aflibercept, (Group 4), dosed 1 week before laser. ×/9 = grade IV lesion score; (C) Box plot, average percentage grade IV lesions after 2nd laser for Groups 1, 2 and 4 and laser for Group 3 (naked dual dAb 2 doses): data across groups, columns = means, vertical lines = full response ranges, circles = means (ADA negative animals), ***P < 0.001, (D) Box plot, individual lesion grades, after 2nd laser for Groups 1, 2, 4 and laser for Group 3, (naked dual dAb: 2 doses). Boxes show 25th to 75th percentiles, (box absence means both percentiles equal a lesion grade of 1), vertical lines = full response ranges, circles = median.