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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Curr Opin Chem Biol. 2017 Apr 8;38:87–96. doi: 10.1016/j.cbpa.2017.03.014

Table 1.

Select antimicrobial peptides, amino acid sequences and properties1

Class Peptide Amino acid sequence Length Net charge Pho Boman index Source APD ID
I Gramicidin A VGALAVVVWLWLWLW 15 0 93% −3.3 Bacteria 499
Magainin 2 GIGKFLHSAKKFGKAFVGEIMNS 23 +3 43% 0.41 Amphibians 144
LL-37 (cathelicidin) LLGDFFRKSKEKIGKEFKRIVQRIKFLRNLVPRTES 37 +6 35% 3.0 human 310
Pyrrhocoricin (PrAMP) VDKGSYLPRPTPPRPIYNRN 20 +3 15% 3.2 insects 170
II Nisin A (lantibiotic) ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK 34 +3 44% 0.37 Bacteri 205
HNP1 (α-defensin) ACYCRIPACIAGERRYGTCI YQGRLWAFCC 30 +3 53% 1.1 Human 176
TAP (β-defensin) NPVSCVRNK GICVPIRCPGSMKQIGTCVGRAVKCCRKK 38 +9 42% 1.7 Bovine 235
Plectasin GFGCNGPWD EDDMQCHNH CKSIKGYKGGYCAKGGFVCKCY 40 +1 32% 1.4 Fungi 549
III Colistin XTXXKLLXXT 10 +6 20% 2.9 Bacteria 2204
Daptomycin WNDTGKDADGSEY 13 −3 15% 3.5 Bacteria 2203
Microcin J25 (bacteriocin) VGIGTPIFSYGGGAGHVPEYF 21 −1 33% −0.64 Bacteria 480
Alamethicin (peptaibol) PBABAQBVBGLBPVBBEQ 18 −1 66% −0.68 Fungi 2197
IV Gramicidin S VKLFPVKLFP 10 2 60% −1.3 Bacteria 2243
Subtilosin A (bacteriocin) NKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG 35 −2 51% −0.46 bacteria 928
Kalata B1 (cyclotide) GLPVCGETCVGGTCNTPG CTCSWPVCTRN 29 0 37% 0.67 Plants 729
RTD-1 (θ-defensin) GFCRCLCRRGVCRCICTR 18 5 55% 2.8 Monkey 445
1

Data taken from the APD (http://aps.unmc.edu/AP), where Pho = hydrophobic%, B = α-aminoisobutyric acid and X = 2,4-diaminobutanoic acid. Boman index was originally called protein-binding potential by Boman [5]. Additional information, including the original reference, can be found in the APD. A unified peptide classification has been proposed [83] and adopted in the APD. This classification is based on the covalent bonding patterns of polypeptides. Class I (or UCLL) contains all linear peptides where both the backbone and sidechains may be modified but do not lead to a loop structure. Class II (or UCSS) contains peptides with a sidechain-sidechain connection, irrespective of intra or inter-connections. Class III (or UCSB) peptides must contain a covalent bond between backbone and sidechain, while class IV (or UCBB) consists of circular peptides due to a bond between backbone and backbone [83].