Skip to main content
. 2017;18(4):905–915. doi: 10.22034/APJCP.2017.18.4.905

Figure 5.

Figure 5

Effects of EL on MMP-2, MMP-9, TIMP-1 and TIMP-2 Gene Expressions in MDA-MB-231 Cells. (A) Decreased gene expression of MMP-2 in MDA-MB-231 cells with 25, 50 and 75 μM concentrations of EL after 24 and 48 hours of incubation in a dose and time dependent manner. (B) Decreased gene expression of MMP-9 in MDA-MB-231 cells with 25, 50 and 75 μM concentrations of EL after 24 and 48 hours of incubation in a dose and time dependent manner. (C) Increased gene expression of TIMP-1 in MDA-MB-231 cells with 25, 50 and 75 µM concentrations of EL after 24 and 48hours of treatment. (D) Increased gene expression of TIMP-1 in MDA-MB-231 cells with 25, 50 and 75 µM concentrations of EL after 24 and 48 hours of treatment, compared to the untreated cells as a negative control and 0.5 µM of TAM as a positive control. Values are represented as mean ± SEM of three independent experiments (n =3) with *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, indicating statistical significance.