Table 3.

Association between midlife elevated blood glucose and neuropathology stratified by APOE ε4 status (for those interactions where p < 0.10)

	Elevated Blood Glucose β ± SE (p)
AD pathology
Medial temporal AT8 NFT      APOE ε4−      APOE ε4+	0.30±1.04 (0.771) 7.41±2.26 (0.006)
Braak and Braak Stage      APOE ε4−      APOE ε4+	−0.91±0.61 (0.140) 3.54±1.12 (0.007)

β represents difference in adjusted means; SE = standard error; AD = Alzheimer’s disease; NFT = neurofibrillary tangles; APOE = apolipoprotein E

All models are adjusted for age; sex; time between midlife vascular risk assessment and death; and obesity, systolic blood pressure, total cholesterol, and smoking status at midlife