Table 4.

Main effect of APOE genotype, main effect of elevated blood glucose (EBG), and interaction between APOE genotype and EBG on neuropathological and clinical diagnosis

Neuropathological Diagnosis	APOE ε4 OR [95% CI]	Elevated Blood Glucose (EBG) OR [95% CI]	Interaction between APOE genotype and EBG p value
Alzheimer’s disease (Braak and Braak Stage)	4.46 [1.50–13.29]**	1.62 [0.48–5.47]	0.200
Alzheimer’s disease (NIA/Reagan)	5.77 [1.88–17.70]**	1.32 [0.41–4.30]	0.560
Clinical Diagnosis
Cognitively normal	Ref	Ref
Mild cognitive impairment	2.17 [0.40–11.94]	2.59 [0.41–16.33]	0.999
Dementia (all forms)	5.63 [1.50–21.20]**	2.73 [0.71–10.55]	0.963
Alzheimer’s disease	8.66 [1.68–44.77]**	2.18 [0.45–10.62]	0.952

^*p<0.05,

^**p≤0.01

Abbreviations: OR = odds ratio; CI = confidence interval; APOE = apolipoprotein E; NIA = National Institute on Aging

All models are adjusted for age; sex; time between midlife vascular risk assessment and death; and obesity, systolic blood pressure, total cholesterol, and smoking status at midlife