Table 2. Body-site distribution of initial involvement area.

Initial involved area	No. (%) of adult AD patients		P value
	Pre-adult-onset (< 18 yr; n = 232)	Adult-onset (≥ 18 yr; n = 48)
Total			0.017*
Head and neck	38 (16.4)	11 (22.9)	0.278
Flexor surface of arms and legs	119 (51.3)	14 (29.2)	0.005†
Trunk	65 (28.0)	21 (43.8)	0.031*
Extensors (elbows/knees/other aspects of limbs)	2 (0.9)	1 (2.1)	0.432‡
Hands and feet	6 (2.6)	1 (2.1)	1.000‡
Genital area	2 (0.9)	0 (0.0)	1.000‡

AD = atopic dermatitis.

^*P < 0.050; ^†P < 0.010; ^‡Data were analyzed using the Fisher exact test. The others were analyzed using the χ² test.