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. 2005 Feb 9;102(8):3064–3069. doi: 10.1073/pnas.0404712102

Fig. 5.

Fig. 5.

Effects of neutralization of BDNF and NT4. (A) Neutralizing NT4 after tectal NT4 transfection prevented the induction of NPY. (B) Neutralizing BDNF after tectal BDNF transfection prevented the induction of NPY. (C) Neutralization of BDNF after tectal transfection of NT4 did not prevent the induction of NPY. (D) It seems that BDNF needs endogenous NT4 signaling as a cofactor. In contrast, neutralization of BDNF in corticotectal OTC does not prevent the up-regulation of NPY by tectal NT4 transfection. (E) Mean percentage (with SEM) of NPY neurons in the experimental conditions of A–D. White matter is oriented downward. (Scale bar: 300 μm.) ***, P < 0.001, tested against VC-SC-deprived (Fig. 4B).