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. 2005 Feb 9;102(8):3064–3069. doi: 10.1073/pnas.0404712102

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Copyright © 2005, The National Academy of Sciences

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Fig. 6. — The source-to-sink model. NT4 overexpressers in the tectal explant () become a source of NT4. Nonoverexpressing pyramidal neurons in layer V of the cortical explant () represent a first sink of NT4 and retrogradely import the factor (a). Now, layer V pyramidal neurons () accumulate NT4 and represent a source of NT4 for cortical interneurons (). They, in turn, represent the second sink of NT4 and either retrieve somatic or dendritic released imported NT4 (b) or receive imported NT4 by anterograde delivery via pyramidal cell axon collaterals (c). The model also explains the results obtained in corticocortical cocultures; in addition, transfected projection neurons may directly deliver NT4 anterogradely to neurons in nontransfected explants.

Inline graphic — The source-to-sink model. NT4 overexpressers in the tectal explant () become a source of NT4. Nonoverexpressing pyramidal neurons in layer V of the cortical explant () represent a first sink of NT4 and retrogradely import the factor (a). Now, layer V pyramidal neurons () accumulate NT4 and represent a source of NT4 for cortical interneurons (). They, in turn, represent the second sink of NT4 and either retrieve somatic or dendritic released imported NT4 (b) or receive imported NT4 by anterograde delivery via pyramidal cell axon collaterals (c). The model also explains the results obtained in corticocortical cocultures; in addition, transfected projection neurons may directly deliver NT4 anterogradely to neurons in nontransfected explants.