Fig. 1.

Experimental protocol. 1, Presurgical period (acclimatization-adaptation period, initial sedation, muscular paralysis, endotracheal intubation); 2, surgical period (catheters insertion: carotid and pulmonary artery, internal jugular vein, mesenteric vein; laparotomy: jejunal tonometer insertion; cystostomy; jejunal ostomy preparation); 3, serial measurements [arterial, mixed-venous, and mesenteric-venous blood sampling; jejunal tonometric measurements; acquisition of microcirculation images (jejunal mucosa, jejunal serosa, sublingual mucosa)]. BL, baseline; TS, time of shock; T2H, 2 h after starting resuscitation; T6H, 6 h after starting resuscitation.