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. 2017 May 30;36(13):1837–1853. doi: 10.15252/embj.201796516

Figure 7. Reduced cerebral glucose metabolism in Trem2 p.T66M knock‐in mice.

Figure 7

  1. Analysis of blood glucose levels at the time point of FDG‐μPET analysis shows no significant differences between wild‐type (wt) and homozygous Trem2 p.T66M knock‐in mice (hom) (n wt = 6; n hom = 9 mice). Data are represented as mean ± SEM. Student's t‐test; n.s., P > 0.05.
  2. Axial (A1) and coronal (C1–3) slices of FDG μPET imaging (scaled by %ID and body weight) and normalized to blood glucose level are projected on a T1 MRI mouse template (left: cerebellum; right frontal pole). Averaged images (n wt = 6; n hom = 9 mice) show a clear visual decrease of FDG signal in several brain areas in Trem2 p.T66M knock‐in mice at 12 months of age when compared to age‐ and sex‐matched wt controls.
  3. Quantitative FDG μPET signal in wt and hom mice. Data are represented as mean ± SEM. Student's t‐test; **P < 0.01 (n wt = 6; n hom = 9 mice).
  4. Dual quantitative μPET shows a significant positive correlation of global cerebral FDG and TSPO signals in homozygous Trem2 p.T66M knock‐in mice (hom). Pearson product–moment correlation.

Source data are available online for this figure.