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. 2017 May 29;36(13):1981–1991. doi: 10.15252/embj.201695890

Figure 1. PAR‐1 is required for sensory neuron dendrite pruning.

Figure 1

  • A–D′
    Loss of PAR‐1 causes defects in c4da neuron dendrite pruning. Upper panels (A–D) show third‐instar larval neurons, and lower panels (A′–D′) show neurons at 18 h APF. (A, A′) Control c4da neurons labeled by UAS‐CD8GFP expression under the control of ppk‐GAL4 (third chromosome insertion). (B, B′) C4da neurons expressing par‐1 RNAi under ppk‐GAL4. (C, C′) MARCM clones of par‐1 Δ16 mutant c4da neurons. (D, D′) Rescue of par‐1 Δ16 mutant MARCM c4da neuron pruning defects by UAS‐mediated expression of wild‐type PAR‐1 (isoform RR).
  • E
    Percentages of neurons with dendrite pruning defects. ***P < 0.0005, *P < 0.05 (using Fisher's exact test). N = 16–38.
  • F
    Number of attached primary and secondary dendrites at 18 h APF. ***P < 0.0005, **P < 0.005 (using Wilcoxon's test). N = 16–38.
  • G
    Length of unpruned dendrites at 18 h APF. ***P < 0.0005 (using Wilcoxon's test). N = 16–38.
Data information: Scale bars are 100 μm in (A–D) and 50 μm in (A′–D′). Error bars represent s.d.