Table 2.
Univariate and multivariate analysis for OS of NSCLC patients
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| Median OS (months) | HR (95% CI) | P | β | HR (95% CI) | P | |
| Age | ||||||
| ≥55 years vs. <55 years | 67.1 vs. 74.1 | 1.118 (0.957,1.305) | 0.160 | |||
| Gender | ||||||
| Males vs. females | 67.8 vs 76.0. | 1.160 (0.985,1.365) | 0.075 | −0.048 | 0.953 (0.754,1.203) | 0.684 |
| Smoking status | ||||||
| Ever vs. never | 64.7 vs. 76.0 | 1.204 (1.038,1.397) | 0.014 | 0.191 | 1.211 (0.978,1.499) | 0.079 |
| Pathology | ||||||
| Squamous vs. non‐squamous | 72.4 vs. 69.2 | 1.001 (0.860,1.166) | 0.998 | |||
| pT category | ||||||
| 3/4 vs. 1/2 | 30.6 vs. 80.9 | 2.084 (1.761,2.466) | <0.001 | 0.415 | 1.514 (1.257,1.825) | <0.001 |
| pN category | ||||||
| ≥ N1 vs. N0 | 40.7 vs. NA | 2.899 (2.497,3.365) | <0.001 | 0.820 | 2.271 (1.804,2.858) | <0.001 |
| pTNM stage | ||||||
| III vs. I–II | 33.8 vs. 109.1 | 2.962 (2.559,3.428) | <0.001 | 0.439 | 1.551 (1.232,1.952) | <0.001 |
| Chemotherapy | ||||||
| No vs. yes | 85.0 vs. 58.5 | 1.385 (1.197,1.601) | <0.001 | −0.258 | 0.772 (0.654,0.912) | 0.002 |
| Surgery type | ||||||
| Pneumonectomy vs. others | 28.4 vs. 72.5 | 1.783 (1.389,2.289) | <0.001 | 0.150 | 1.162 (0.897,1.504) | 0.256 |
| NWR | ||||||
| High group vs. low group | 63.2 vs. 90.7 | 1.379 (1.168,1.629) | <0.001 | 0.277 | 1.319 (1.057,1.645) | 0.014 |
| LWR | ||||||
| High group vs. low group | 82.3 vs. 59.3 | 0.746 (0.644,0.863) | <0.001 | 0.039 | 1.040 (0.769,1.406) | 0.800 |
| MWR | ||||||
| High group vs. low group | 59.8 vs. 74.6 | 1.195 (1.022,1.398) | 0.026 | 0.112 | 1.118 (0.926,1.351) | 0.245 |
| NLR | ||||||
| High group vs. low group | 59.7 vs. 82.5 | 1.351 (1.166,1.566) | <0.001 | −0.048 | 0.954 (0.690,1.318) | 0.773 |
| MLR | ||||||
| High group vs. low group | 53.2 vs. 76.6 | 1.493 (1.281,1.740) | <0.001 | 0.224 | 1.252 (1.016,1.542) | 0.035 |
| PLR | ||||||
| High group vs. low group | 50.5 vs. 72.2 | 1.406 (1.126,1.755) | 0.003 | 0.053 | 1.055 (0.831,1.340) | 0.661 |
| PWR | ||||||
| High group vs. low group | 63.7 vs. 72.2 | 1.123 (0.962,1.312) | 0.141 | |||
β, partial regression coefficient; CI, confidence interval; HR, hazard ratio; LWR, lymphocyte/white blood cell ratio; MLR, monocyte/lymphocyte ratio; MWR, monocyte/white blood cell ratio; NA, not available; NSCLC, non‐small cell lung cancer; NLR, neutrophil/lymphocyte ratio; NWR, neutrophil/white blood cell ratio; OS, overall survival; PLR, platelet/lymphocyte ratio; pN, pathologic node; pT, pathologic tumor; pTNM, pathologic tumor node metastasis; PWR, platelet/white blood cell ratio.