Table 1.
Main autophagy‐related proteins in common model organisms.a
| Homo sapiens | Mus musculus | Drosophila melanogaster | Caenorhabditis elegans | Saccharomyces cerevisiae |
|---|---|---|---|---|
| ACBD3 (PMP70) | ACBD3 | Pmp70 | PMP‐2 | – |
| ACBD5 | ACBD5 | – | – | Atg37 |
| AMBRA1 | AMBRA1 | – | – | – |
| ATG2A, ATG2B | ATG2A, ATG2B | Atg2 | ATG‐2 | Atg2 |
| ATG3 | ATG3 | Atg3 | ATG‐3 | Atg3 |
| ATG4A, ATG4B, ATG4C, ATG4D | ATG4A, ATG4B, ATG4C, ATG4D | Atg4a, Atg4b | ATG‐4.1, ATG‐4.2 | Atg4 |
| ATG5 | ATG5 | Atg5 | ATG‐5 | Atg5 |
| ATG7 | ATG7 | Atg7 | ATG‐7 | Atg7 |
| ATG9A, ATG9B | ATG9A, ATG9B | Atg9 | ATG‐9 | Atg9 |
| ATG10 | ATG10 | Atg10 | ATG‐10 | Atg10 |
| ATG12 | ATG12 | Atg12 | LGG‐3 | Atg12 |
| ATG13 | ATG13 | Atg13 | EPG‐1 (ATG‐13) | Atg13 |
| ATG14 (ATG14L) | ATG14 (ATG14L) | Atg14 | EPG‐8 | Atg14 |
| ATG16L1 | ATG16L1 | Atg16 | ATG‐16.1, ATG‐16.2 | Atg16 |
| ATG101 | ATG101 | Atg101 | EPG‐9 | – |
| BCL2 | BCL2 | Debcl | CED‐9 | – |
| BCL2L13 | BCL2L13 | – | – | – |
| BECN1 | BECN1 | Atg6 | BEC‐1 | Atg6 |
| BNIP3 (NIP3) | BNIP3 | – | DCT‐1 | – |
| BNIP3L (NIX) | BNIP3L | – | – | – |
| CALCOCO2 (NDP52) | CALCOCO2 (NDP52) | – | – | – |
| – | – | – | EPG‐2 | – |
| EI24 (EPG4) | EI24 (EPG4) | tank | EPG‐4 | – |
| EPG5 | EPG5 | Epg5 | EPG‐5 | – |
| ENDOG | ENDOG | EndoG, Tengl1, Tengl2, Tengl3, Tengl4 | CPS‐6 | Nuc1 |
| FAM134B | FAM134B | – | – | Atg40 |
| FANCC | FANCC | – | – | – |
| FUNDC1 | FUNDC1 | – | T06D8.7 | – |
| GFAP | GFAP | – | – | – |
| HSP90AA1 | HSP90AA1 | Hsp83 | DAF‐21 | Hsc82, Hsp82 |
| HSPA8 (HSC70) | HSPA8 (HSC70) | Hsc70‐1, Hsc70‐2, Hsc70‐3, Hsc70‐4, Hsc70‐5, Hsc70‐6, Hsc70Cb | HSP‐70 | Ssa1, Ssa2, Ssa3, Ssa4 |
| INPP5E | INPP5E | Inpp5e | – | – |
| LAMP1 | LAMP1 | Lamp1 | LMP‐1, LMP‐2 | – |
| LAMP2 | LAMP2 | – | – | – |
| LGALS3 | LGALS3 | – | – | – |
| LGALS8 | LGALS8 | – | – | – |
| MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1, GABARAPL2 | MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1, GABARAPL2b | Atg8a, Atg8b | LGG‐1, LGG‐2 | Atg8 |
| MTOR | MTOR | Tor | LET‐363 | Tor1 |
| NBR1 | NBR1 | – | – | – |
| NRBF2 | NRBF2 | – | – | Atg38 |
| OPTN | OPTN | – | – | – |
| PARK2 | PARK2 | park | PDR‐1 | – |
| PEX2 | PEX2 | Pex2 | PRX‐2 | Pex2 |
| PEX3 | PEX3 | Pex3 | PRX‐3 | Pex3 |
| PEX5 | PEX5 | Pex5 | PRX‐5 | Pex5 |
| PEX13 | PEX13 | Pex13 | PRX‐13 | Pex13 |
| PEX14 | PEX14 | Pex14 | PRX‐14 | Pex14 |
| PHB2 | PHB2 | Phb2 | PHB‐2 | Phb2 |
| PIK3C3 (VPS34) | PIK3C3 (VPS34) | Pi3K59F | VPS‐34 | Vps34 |
| PIK3R4 (VPS15) | PIK3R4 (VPS15) | Vps15 | VPS‐15 | Vps15 |
| PINK1 | PINK1 | Pink1 | PINK‐1 | – |
| PLEKHM1 | PLEKHM1 | CG6613 | Y51H1A.2 | – |
| PSMD4 (RPN10) | PSMD4 (RPN10) | Rpn10 | RPN‐10 | Rpn10 |
| RAB7A, RAB7B | RAB7A, RAB7B | Rab7 | RAB‐7 | Ypt7 |
| RAB11A | RAB11A | Rab11 | RAB‐11.1, RAB‐11.2 | Ypt31, Ypt32 |
| RB1CC1 (FIP200) | RB1CC1 | Atg17 | EPG‐7 | Atg11, Atg17 |
| RNF166 | RNF166 | – | – | – |
| RUBCN (RUBICON) | RUBCN (RUBICON) | CG12772 | – | – |
| SMURF1 | SMURF1 | Smurf | – | – |
| SNX4 | SNX4 | – | SNX‐3 | Snx4 (Atg24) |
| SNX18 | SNX18 | Sh3px1 | SNX‐9 | – |
| SQSTM1 (p62) | SQSTM1 (p62) | ref(2)P | SQST‐1, SQST‐2, SQST‐3, SQST‐4 | – |
| STX17 | STX17 | Syx17 | VF39H2L.1 | – |
| TAX1BP1 | TAX1BP1 | – | – | – |
| TBK1 | TBK1 | LOC108141996 | – | – |
| TECPR1 | TECPR1 | – | – | – |
| TFEB | TFEB | Mitf | HLH‐30 | – |
| TGM2 | TGM2 | Tg | – | – |
| TOLLIP | TOLLIP | – | TLI‐1 | Cue5 |
| TRIM5 | TRIM5 | – | – | – |
| ULK1 (ATG1), ULK2 | ULK1 (ATG1), ULK2 | Atg1 | UNC‐51 | Atg1 |
| UVRAG | UVRAG | Uvrag | T23G11.7, Y34BA.2 | Vps38 |
| VCP | VCP | TER94 | CDC‐48.1, CDC‐48.2 | Cdc48 |
| WDFY3 (ALFY) | WDFY3 (ALFY) | bchs | WDFY‐3 | – |
| WIPI1, WIPI2, WDR45B (WIPI3), WDR45 (WIPI4) | WIPI1, WIPI2, WDR45B (WIPI3), WDR45 (WIPI4) | Atg18a, Atg18b | ATG‐18, EPG‐6 | Atg18, Atg21 |
| VMP1 | VMP1 | Tango5 | EPG‐3 | – |
| WAC | WAC | Wac | – | – |
| ZFYVE1 (DFCP1) | ZFYVE1 (DFCP1) | – | – | – |
Yeast proteins with no known orthologues in C. elegans, D. melanogaster, M. musculus or H. sapiens: Atg19, Atg20, Atg23, Atg26, Atg27, Atg29, Atg30, Atg31, Atg32, Atg33, Atg34, Atg36, Atg39, Bre5, Doa1, Hsp104, Ubp3, Uth1.
a
Excluding non‐coding pseudogenes, as per https://www.ncbi.nlm.nih.gov/gene/; common aliases are indicated between brackets.
b
Correction added on 3 July 2017, after first online publication: the protein MAP1LC3C has been deleted.