Figure 1. Phosphatase‐inactive laforin does not correct LD muscle glycogen hyperphosphorylation, but does correct its chain length distribution and prevents abnormal glycogen accumulation.

Laf indicates WT laforin and C265Laf indicates phosphatase‐inactive laforin transgenes, respectively, expressed in indicated LD mouse model (Epm2a ^−/−).

1. Glycogen content.
2. Glycogen total phosphate content.
3. Glycogen carbon C6 phosphate content.
4. Chain length distribution analyses.

Data information: Means of > 5 biological replicates are presented as bars in (A–C) or as circles in (D). Standard deviations are presented as error bars in (A–C), or as blue (WT), red (Epm2a ^−/−) or grey shades (Epm2a ^−/−.Laf and Epm2a ^−/−.C265SLaf) in (D). Asterisks, statistical significance by ANOVA and post hoc analyses (*P < 0.05, **P < 0.01, ***P < 0.001; Appendix Table S1).