Skip to main content
. 2017 May 24;9(7):950–966. doi: 10.15252/emmm.201607265

Table 3.

Clinical GSIs differentially inhibit SPPL2b (IC50s in nM)

γ‐secretasea SPPL2b
BMS‐906024 0.29 28.34
RO4929097 1.88 72.85
PF‐3084014 0.37 1159.47
a

The average of IC50s on cNOTCH1sub, cNOTCH2sub, cNOTCH4sub, and APP.