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. 2017 May 23;18(7):1199–1212. doi: 10.15252/embr.201743897

Figure 4. Identification of oscillatory transcripts at D15 and D30.

Figure 4

  1. 643 and 757 oscillators for D15 and D30 cultures, as analyzed using JTK‐cycle (adj. P < 0.05). Heatmaps represent z‐normalized RPM values of the average of three independent replicates. Oscillatory genes were ranked by their phase of expression and visualized using Java TreeView.
  2. Venn diagram of JTK‐cycle detected oscillators for D15 and D30.
  3. Fraction of JTK‐cycle detected oscillators that were previously found to be rhythmically expressed in mouse hearts 14.
  4. Examples of overlapping oscillators between D15, D30 cardiac cells and mouse hearts. Average log2 RPM read counts of three replicates, smoothened over 2 time points ± s.e.m., were plotted. Significance of rhythmicity across 48 h was analyzed using the JTK‐cycle algorithm (* JTK P < 0.05, ** JTK P < 0.005, and *** JTK P < 0.0005).