Fig. 5.

FSK and Ro-20–1724 increase the mIPSC frequency in the WT mice but not in the KO mice. (A) Representative traces before [top two traces, from WT (Left)orKO(Right) mice] and after (bottom two traces) 5 μM FSK application. (B) FSK induced a shift in the cumulative probability histogram of interevent intervals in WT (Left) that was occluded by the higher basal mIPSC frequency in KO (Right) animals. (C and D) The increase of the mIPSC frequency observed in WT mice with the PDE inhibitor, Ro-20-1724, was occluded in KO mice. (Scale bars, 50 pA/2 s.)