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Similar overall cAMP concentration between genotypes. Measuring the total concentration of cAMP normalized to the total protein content of homogenates obtained from cortex (31.2 ± 2.3 vs. 34.7 ± 2.8 pmol/mg) and midbrain (17.9 ± 1.3 vs. 19.2 ± 2.1 pmol/mg) of WT and β-arrestin2 KO mice did not show any significant difference between the genotypes (P < 0.05, n = 3).
