Table 6.
Analysis of kalirin genotypic association with IS in subgroups.
| rs7620580 | ||||
|
| ||||
| Gender | ||||
|
| ||||
| Genotype | Woman | Man | ||
| OR (95% CI) | OR (95% CI)∗ | OR (95% CI) | OR (95% CI)∗∗ | |
|
| ||||
| AG | 1.368 (0.866–2.162) | 1.988 (1.035–3.816) ▲ | 1.723 (1.154–2.572) ▲▲ | 1.776 (1.096–2.877) |
| GG | 1.583 (0.433–5.796) | 2.236 (0.410–12.201) | 2.135 (0.864–5.277) | 3.661 (1.215–11.036) |
| Recessive | 1.397 (0.387–5.048) | 1.682 (0.319–8.876) | 1.716 (0.704–4.179) | 2.895 (0.982–8.541) |
| Additive | 1.334 (0.896–1.987) | 1.804 (1.032–3.152) ▲ | 1.608 (1.158–2.233) ▲▲ | 1.832 (1.235–2.719) ▲▲ |
| Dominant | 1.383 (0.884–2.163) | 2.007 (1.062–3.793) ▲ | 1.766 (1.200–2.600) ▲▲ | 1.923 (1.206–3.067) ▲▲ |
|
| ||||
| BMI | ||||
|
| ||||
| Genotype | BMI < 25 kg/m2 | BMI ≥ 25 kg/m2 | ||
| OR (95% CI) | OR (95% CI)∗∗∗ | OR (95% CI) | OR (95% CI)∗∗∗∗ | |
|
| ||||
| AA | 1 | 1 | 1 | 1 |
| AG | 1.658 (1.157–2.377) ▲▲ | 1.598 (0.999–2.557) | 1.302 (0.744–2.278) | 1.966 (0.887–4.357) |
| GG | 2.200 (0.866–5.462) | 3.055 (0.918–10.166) | 1.319 (0.367–4.744) | 4.130 (0.858–19.874) |
| Recessive | 1.802 (0.734–4.422) | 2.565 (0.781–8.424) | 1.181 (0.335–4.157) | 3.105 (0.681–14.156) |
| Additive | 1.593 (1.175–2.160) ▲▲ | 1.651 (1.112–2.451) ▲ | 1.236 (0.780–1.959) | 1.999 (1.077–3.711) ▲ |
| Dominant | 1.703 (1.200–2.416) ▲▲ | 1.699 (1.077–2.680) ▲ | 1.304 (0.758–2.241) | 2.188 (1.019–4.700) ▲ |
|
| ||||
| rs2289843 | ||||
|
| ||||
| Gender | ||||
|
| ||||
| Genotype | Woman | Man | ||
| OR (95% CI) | OR (95% CI)∗ | OR (95% CI) | OR (95% CI)∗∗ | |
|
| ||||
| TT | 1 | 1 | 1 | 1 |
| TA | 1.070 (0.643–1.779) | 1.443 (0.687–3.033) | 1.203 (0.763–1.895) | 1.421 (0.825–2.446) |
| AA | 1.635 (0.842–3.175) | 2.782 (1.134–6.826) ▲ | 1.113 (0.656–1.891) | 1.208 (0.645–2.264) |
| Recessive | 1.565 (0.879–2.787) | 2.186 (1.035–4.620) ▲ | 0.989 (0.636–1.539) | 0.970 (0.573–1.642) |
| Additive | 1.250 (0.903–1.730) | 1.658 (1.059–2.595) ▲ | 1.059 (0.813–1.380) | 1.108 (0.810–1.515) |
| Dominant | 1.192 (0.734–1.936) | 1.765 (0.872–3.570) | 1.172 (0.765–1.796) | 1.344 (0.810–2.231) |
|
| ||||
| BMI | ||||
|
| ||||
| Genotype | BMI < 25kg/m2 | BMI ≥ 25 kg/m2 | ||
| OR (95% CI) | OR (95% CI)∗∗∗ | OR (95% CI) | OR (95% CI)∗∗∗∗ | |
|
| ||||
| TT | 1 | 1 | 1 | 1 |
| TA | 1.033 (0.692–1.541) | 1.134 (0.678–1.897) | 1.490 (0.782–2.839) | 1.889 (0.733–4.866) |
| AA | 1.129 (0.686–1.858) | 1.370 (0.723–2.596) | 1.548 (0.737–3.252) | 1.569 (0.581–4.241) |
| Recessive | 1.106 (0.722–1.693) | 1.266 (0.730–2.197) | 1.202 (0.646–2.236) | 1.071 (0.474–2.420) |
| Additive | 1.060 (0.827–1.357) | 1.167 (0.850–1.602) | 1.250 (0.860–1.817) | 1.238 (0.754–2.034) |
| Dominant | 1.059 (0.724–1.548) | 1.197 (0.736–1.947) | 1.510 (0.818–2.756) | 1.741 (0.740–4.097) |
|
| ||||
| rs1708303 | ||||
|
| ||||
| Gender | ||||
|
| ||||
| Genotype | Woman | Man | ||
| OR (95% CI) | OR (95% CI)∗ | OR (95% CI) | OR (95% CI)∗∗ | |
|
| ||||
| AA | 1 | 1 | 1 | 1 |
| AG | 1.613 (0.996–2.612) | 1.663 (0.846–3.272) | 1.444 (0.947–2.202) | 1.497 (0.901–2.487) |
| GG | 2.204 (0.644–7.548) | 1.191 (0.236–6.015) | 1.063 (0.261–4.330) | 0.875 (0.168–4.564) |
| Recessive | 1.886 (0.556–6.394) | 1.020 (0.205–5.072) | 0.953 (0.235–3.863) | 0.778 (0.150–4.034) |
| Additive | 1.566 (1.045–2.345) ▲ | 1.414 (0.809–2.470) | 1.332 (0.914–1,941) | 1.331 (0.848–2.090) |
| Dominant | 1.665 (1.046–2.652) ▲ | 1.602 (0.837–3.068) | 1.417 (0.938–2.141) | 1.447 (0.881–2.374) |
|
| ||||
| BMI | ||||
|
| ||||
| Genotype | BMI < 25 kg/m2 | BMI ≥ 25 kg/m2 | ||
| OR (95% CI) | OR (95% CI)∗∗∗ | OR (95% CI) | OR (95% CI)∗∗∗∗ | |
|
| ||||
| AA | 1 | 1 | 1 | 1 |
| AG | 1.590 (1.094–2.309) ▲ | 1.368 (0.841–2.227) | 1.450 (0.783–2.686) | 2.435 (1.003–5.912) ▲ |
| GG | 1.261 (0.433–3.674) | 0.969 (0.248–3.781) | 3.807 (0.434–33.355) | 2.035 (0.164–25.291) |
| Recessive | 1.086 (0.375–3.140) | 0.880 (0.227–3.417) | 3.437 (0.395–29.930) | 1.651 (0.136–20.089) |
| Additive | 1.431 (1.036–1.978) ▲ | 1.232 (0.813–1.867) | 1.564 (0.912–2.683) | 2.095 (0.962–4.562) |
| Dominant | 1.561 (1.086–2.244) ▲ | 1.329 (0.829–2.131) | 1.557 (0.854–2.840) | 2.397 (1.018–5.644) ▲ |
∗adjusted for age, SBP, and drinking history in men; ∗∗adjusted for age, SBP, LDL-C, and smoking history in women; ∗∗∗adjusted for age, SBP, LDL-C, and smoking history in BMI < 25 kg/m2; ∗∗∗∗adjusted for age, SBP, LDL-C, and smoking history in BMI ≥ 25 kg/m2; ▲p < 0.05, ▲▲p < 0.01.