Table 3.
Whole body metabolic information obtained with PULSE model
| Parameter | Unit | Healthy | Sepsis | P Value |
|---|---|---|---|---|
| Extracellular pool (Q1) | µmol/kg BW | 44 ± 2.2 | 68 ± 5.5 | 0.002 |
| Intracellular pool (Q2) | µmol/kg BW | 105 ± 8.0 | 157 ± 8.2 | 0.0003 |
| Flux (F12 = F21) | µmol·kg BW−1·min−1 | 5.02 ± 0.40 | 6.86 ± 0.42 | 0.006 |
| Shunting (F12-WbRa) | µmol·kg BW−1·min−1 | 3.02 ± 0.35 | 4.23 ± 0.34 | 0.026 |
| Irreversible loss (F02) | µmol·kg BW−1·min−1 | 3.38 ± 0.10 | 4.33 ± 0.16 | 0.0002 |
| Fractional rate of irreversible loss (k02) | %/min | 3.33 ± 0.21 | 2.83 ± 0.15 | 0.065 |
| Fractional rate of intracellular release (k12) | %/min | 5.09 ± 0.69 | 4.43 ± 0.25 | 0.316 |
| Fractional rate of intracellular uptake (k21) | %/min | 11.5 ± 0.71 | 10.6 ± 0.76 | 0.423 |
Mean values of parameters obtained and calculated from the fitting of individual decay curves of Phe enrichment. Values are expressed as means ± SE. Healthy n = 9; Sepsis n = 13. Statistics: unpaired t-test.