Table 4.
C5aR2 agonists and antagonists.
| Ligand | Specificity | Function | Refs |
|---|---|---|---|
| Jun/fos-A8 Jun/fos-A8△71–73 C5 mutant peptides |
Human and murine C5aR1 and C5aR2 | Antagonists—block binding of C5a and C5a des Arg to C5aRs |
[51] |
| P32, P59—C terminal peptides of C5a |
hC5aR2 | Agonists—strongly stimulate the association of hC5aR2 with β-arrestin 2 |
[21, 127] |
| LukS-PV—protein from S. aureus | Human and rabbit C5aR1 Human, macaque, and rabbit C5aR2 |
Antagonist of C5a-induced activation of neutrophils | [48, 128] |
| HIgCB—protein complex from S. aureus |
Human, macaque, rabbit, and cow C5aRs | Antagonist of C5a-induced activation of neutrophils | [128, 129] |