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Vascular remodeling in fbln-5–/– mice after 28 days of ligation. Representative photos of transverse sections at indicated levels stained with hematoxylin/eosin. Wild-type (WT) vessels are shown in Left. Note an increased diameter of the vessel with a thickening of adventitia (a) and thinning of the medial layer (m) in the fbln-5–/– vessel. Thrombus formation (thr) and neovascularization (nv) were observed in the fbln-5–/– mouse. ni, neointima. (Bars, 40 μm.)
