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The A. actinomycetemcomitans essential metabolic network. Dots and lines represent compounds and reactions, respectively. Blue, pathways essential in both strains; green, pathways essential in VT1169 only; red, pathways essential in 624 only. The shaded regions indicate specific metabolites or metabolic pathways. PRPP, phosphoribosyl pyrophosphate; CoA, coenzyme A.
