Table II.
CNV markers associated with bladder cancer risk.
| Location (GRCh37/hg19) | Cytoband | Gene | CNV assay ID | CNV | P-valuea | Bonferroni |
|---|---|---|---|---|---|---|
| chr2:72,218,053–72,222,026 | p13.3 | CYP26B1 | Hs05873524_cn | Gain | <0.0001 | 0.0149 |
| chr2:101,678,677–101,683,846 | q11.2 | MAP4K4 | Hs02074840_cn | Loss | <0.0001 | 0.0040 |
| chr7:1,237,863–1,240,528 | p22.3 | UNCX | Hs03622829_cn | Loss | <0.0001 | 0.0384 |
| chr8:61,752,169–61,756,537 | q12.2 | CHD7 | Hs02866323_cn | Loss | <0.0001 | 0.0149 |
| chr10:64,949,973–64,952,473 | q21.3 | REEP3 | Hs00735097_cn | Loss | <0.0001 | 0.0002 |
| chr11:256,350–257,345 | p15.5 | Non-coding region of the genome | Hs03791448_cn | Loss | <0.0001 | 0.0331 |
| chr14:50,365,069–50,365,879 | q22.1 | NIN | Hs07054232_cn | Loss | <0.0001 | <0.0001 |
| chr15:57,515,723–57,519,569 | q22.2 | FAM81A | Hs59732286_cn | Loss | <0.0001 | 0.0012 |
| chr15:99,843,944–99,844,859 | q26.3 | PCSK6 | Hs03899300_cn | Loss | <0.0001 | 0.0040 |
| chr16:45,732,422–45,736,896 | q12.1 | NETO2 | Hs02817425_cn | Loss | <0.0001 | 0.0012 |
| chr19:35,123,405–35,132,171 | q12 | C19orf2 | Hs07125447_cn | Loss | <0.0001 | <0.0001 |
a
Fisher's exact test. CNV, copy number variation; ID, identity; chr, chromosome; Hs, Homo sapiens; CYP26B1, cytochrome P450 family 26 subfamily B member 1; MAP4K4, mitogen-activated protein kinase kinase kinase kinase 4; UNCX, UNC homeobox; CHD7, chromodomain-helicase-DNA-binding protein 7; REEP3, receptor expression-enhancing protein 3; NIN, ninein; FAM81A, family with sequence similarity 81 member A; PCSK6, proprotein convertase subtilisin/kexin type 6; NETO2, neuropilin and tolloid like 2; C19orf2, chromosome 19 open reading frame 2.