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miR-215 overexpression decreased AKT1 expression in breast cancer cells. (A) miR-215-binding sites in the 3′UTR of AKT1. (B) The miR-215 mimic inhibited the expression of AKT1 at the protein level in MCF-7A and MDA-MB-231 cells. *P<0.05 compared with NC-transfected cells. miR-215, microRNA-215; AKT1, AKT serine/threonine kinase 1; 3′UTR, 3′-untranslated region; Wt, wild-type; mut, mutant; NC, negative control.
