Table III.
Clinicopathological characteristics of the control group (n=20).
| Characteristic | TYMS high, n | TYMS low, n | P-value | DPYD high, n | DPYD low, n | P-value |
|---|---|---|---|---|---|---|
| Age, yearsa | 66 (59–81) | 57.5 (53–78) | 0.05 | 64.5 (53–80) | 63.5 (53–81) | 0.90. |
| Liver function parameters | ||||||
| Child Pugh score | ||||||
| A | 9 | 8 | 0.53 | 8 | 9 | 0.53 |
| B | 1 | 2 | 2 | 1 | ||
| Albumin, g/dla | 4 (3.2–4.2) | 3.65 (3.1–4.2) | 0.20 | 3.8 (3.1–4.2) | 3.65 (3.1–4.2) | 0.59 |
| Cholinesterase, IU/la | 243 (82–318) | 178 (45–282) | 0.15 | 190.5 (82–318) | 243 (45–296) | 0.31 |
| ICG R15, %a | 10 (2.2–47) | 20 (7–59) | 0.07 | 19 (2.2–30) | 13 (5–59) | 0.71 |
| Prothrombin time, %a | 84.9 (81.9–100) | 94.7 (60.4–100) | 0.68 | 90.15 (66.3–100) | 85 (60.4–100) | 0.70 |
| Tumor pathology | ||||||
| Differentiation | ||||||
| Well | 0 | 0 | 1.00 | 0 | 0 | 1.00 |
| Moderate | 8 | 8 | 8 | 8 | ||
| Poor | 2 | 2 | 2 | 2 | ||
| Numbers of tumor | ||||||
| Solitary | 9 | 8 | 0.53 | 7 | 10 | 0.06 |
| Multiple | 1 | 2 | 3 | 0 | ||
| Portal vein invasion | ||||||
| Yes | 2 | 2 | 1.00 | 2 | 2 | 1.00 |
| No | 8 | 8 | 8 | 8 | ||
| Hepatic vein invasion | ||||||
| Yes | 1 | 1 | 1.00 | 0 | 2 | 0.14 |
| No | 9 | 9 | 10 | 8 | ||
| Intrahepatic metastasis | ||||||
| Yes | 1 | 1 | 1.00 | 0 | 2 | 0.14 |
| No | 9 | 9 | 10 | 8 |
a
Data represented as median (range). Child Pugh score (17): A, the sum of the score is 5–6 points; B, the sum of the scores is 7–9 points. N.S., no significance; ICG R15, indocyanine green retention test; DPYD, dihydropyrimidine dehydrogenase; TYMS, thymidylate synthase.