Table 1. Suppression of intestinal polyp development in Min mice by NO-1886.
Small intestine
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Dose, ppm | No. of mice | Proximal | Middle | Distal | Colon | Total |
0 | 7 | 23.1 ± 4.2 | 37.1 ± 11.1 | 60.4 ± 12.2 | 1.0 ± 0.2 | 121.7 ± 26.0 |
400 | 8 | 8.5 ± 1.4 (37)* | 16.1 ± 3.8 (43) | 33.0 ± 6.5 (55) | 0.4 ± 0.2 (38)† | 58.0 ± 10.8 (48)† |
800 | 10 | 5.9 ± 1.0 (26)* | 13.8 ± 2.6 (37)† | 30.5 ± 5.0 (51)† | 0.3 ± 0.2 (30)† | 50.5 ± 7.8 (42)* |
Data are means ± SE of the number of polyps per mouse. Numbers in parentheses are percentages of the control value.
Significantly different from the basal diet group at P < 0.01
Significantly different from the basal diet group at P < 0.05