Table 8.
Correlations of circulating levels of Sirt4 with PREDIMED score, total energy, and daily macronutrient/micronutrient intake.
| Parameters | Circulating levels of Sirt4 (ng/mL) n = 43 |
|||
|---|---|---|---|---|
| Simple correlation | Adjusted for total energy (kcal) | |||
| r | p value | r | p value | |
| PREDIMED score | 0.820 | <0.001 | 0.356 | 0.021 |
| Total energy (kcal) | −0.818 | <0.001 | — | — |
| Protein (% of total kcal) | 0.511 | <0.001 | 0.100 | 0.529 |
| INQ protein | 0.742 | <0.001 | 0.453 | 0.003 |
| Carbohydrate (% of total kcal) | −0.070 | 0.656 | −0.033 | 0.838 |
| INQ carbohydrate | 0.661 | <0.001 | 0.184 | 0.242 |
| Complex (% of total kcal) | 0.395 | 0.009 | 0.082 | 0.606 |
| Simple (% of total kcal) | −0.472 | 0.001 | −0.133 | 0.477 |
| Fat (% of total kcal) | −0.822 | <0.001 | −0.280 | 0.073 |
| INQ Fat | 0.578 | <0.001 | 0.060 | 0.704 |
| SFA (% of total kcal) | −0.730 | <0.001 | −0.370 | 0.016 |
| MUFA (% of total kcal) | 0.739 | <0.001 | 0.138 | 0.384 |
| PUFA (% of total kcal) | −0.124 | 0.430 | 0.050 | 0.754 |
| n-6 PUFA (g/day) | −0.546 | <0.001 | −0.107 | 0.502 |
| n-3 PUFA (g/day) | 0.854 | <0.001 | 0.646 | <0.001 |
| n-6/n-3 PUFAs ratio | −0.541 | <0.001 | 0.123 | 0.438 |
| Cholesterol (mg/day) | −0.336 | 0.028 | −0.007 | 0.964 |
| Fiber (g/day) | 0.305 | 0.047 | −0.026 | 0.872 |
| Retinol Eq (μg/day) | 0.337 | 0.027 | −0.029 | 0.854 |
| Vitamin C (mg/day) | 0.825 | <0.001 | 0.476 | 0.001 |
| Vitamin D (μg/day) | 0.407 | 0.007 | 0.083 | 0.601 |
| Vitamin E (mg/day) | 0.834 | <0.001 | 0.329 | 0.034 |
| Iron (mg/day) | 0.335 | 0.028 | 0.067 | 0.673 |
| Selenium (μg/day) | 0.421 | 0.005 | 0.205 | 0.192 |
| Zinc (mg/day) | 0.505 | 0.001 | 0.020 | 0.900 |
| MAI | 0.833 | <0.001 | 0.435 | 0.004 |
Correlations among variables were performed Spearman's rho correlation coefficients. Circulating levels of Sirt4 were significantly associated with all the macronutrients/micronutrients evaluated in this study, except with carbohydrate and n-6 PUFA. After adjusting for total energy intake, the associations between circulating levels of Sirt4 and the study variables were lost, except for PREDIMED score, the consumption of fat, SFA and n-3 PUFA, and the intake of vitamins C and E. Sirt4: sirtuin 4; PREDIMED: PREvención con DIeta MEDiterránea; INQ: index of nutritional quality; SFA: saturated fatty acids; MUFA: monounsaturated fatty acids; PUFA: polyunsaturated fatty acids; MAI: Mediterranean adequacy index.