Table 2. Personal and Family History of Patients with PDAC Who Underwent Genetic Testing.
A total of 7 patients with PDAC were found to have mutations in BRCA1 or BRCA2.
| BRCA1 Mutation Carriers | BRCA2 Mutation Carriers | No BRCA Mutation | |
|---|---|---|---|
| Number of Subjects | 2 | 5 | 25 |
| Ashkenazi Jewish Subjects | 2 (100%) | 3 (60%) | 21 (84%) |
| Mean Age at Diagnosis (Years +/- SD) | 49.0 +/- 1.4 | 58.4 +/- 8.9 | 61.5 +/- 12.0 |
| Tobacco Use | 0 | 0 | 3 current, 10 previous |
| Heavy Alcohol Use | 0 | 0 | 2 |
| Personal History of Non-PDAC Cancer | 0 | Breast Cancer in 2 | Breast Cancer in 3 Prostate Cancer in 2 Basal Cell Carcinoma in 1 Neuroendocrine in 1 |
| Number of Patients With First-Degree Relatives with PDAC | 0 | 0* | 4 |
| Number of Patients with First-Degree Relatives with Breast or Ovarian Cancer | 1 | 2 | 5 |
One individual had 3 third-degree relatives with PDAC.